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S.A. scientist gets $23M to develop HIV vaccine
July 22, 2016

Ruth Ruprecht, scientist and director of the Texas Biomedical Research Institute's AIDS Research Program in San Antonio, is the principal investigator on a coordinated project to develop an HIV vaccine.

July 22, 2016
By Peggy O'Hare, STAFF WRITER
Express-News

A Texas Biomedical Research Institute scientist in San Antonio working to develop an HIV vaccine has been awarded a $23 million grant for the project.

The five-year project, involving investigators from multiple institutions in the United States and Europe, aims to establish a vaccine that can mount multiple defenses against HIV in a patient's mucosa, blood and tissue.

The effort is being led by principal investigator Ruth Ruprecht, a scientist and director of the Texas Biomed AIDS Research Program.

The $23 million grant was awarded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health. It is the largest NIH project grant ever received by Texas Biomed.

The idea "is to induce host defenses against HIV simultaneously at multiple levels - first at mucosal barriers, then in mucosal tissues and finally in the systemic circulation and the rest of the body," Ruprecht said.

She has formed a team of investigators to work on the project. They work in multiple fields, such as viral pathogenesis, molecular biology, whole body imaging, monoclonal antibody development, immunology, lymph node-targeted vaccine design and animal modeling. pohare@express-news.net

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